THROMBOSPONDIN-1
- 2 independent labs in 2 countries
- Funders: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana and 8 more
- Animals2
- Cells1
Outcomes
2Synaptogenesis
upin mouse cells1
1 study
Synaptogenesis
upin mouse cells1
THROMBOSPONDIN-1 improves synaptogenesis in mouse cells.
“Supplementing senescent ACM with thrombospondin-1 protein or overexpressing thrombospondin-1 gene in senescent astrocytes reinstates synaptogenesis.”
Cellsprotein supplement
Astrocyte Senescence Impairs Synaptogenesis due to Thrombospondin-1 Loss
Aging cell19 Jan 2026
CD47 cluster size
upin mouse cells1
1 study
CD47 cluster size
upin mouse cells1
THROMBOSPONDIN-1 increases CD47 cluster size in mouse cells.
“Exposure of aged RBCs to TSP-1 resulted in a further increase in the size of CD47 clusters via a lipid raft-dependent mechanism.”
Cellsin aged red blood cellsred blood cells
Aging cell31 Aug 2020
Funding
1 grant since 2018American Heart AssociationUS$300k
Latest
2 in 12 monthsReproductive Sciences
The KAT5-TSP-1 Axis Maintains Ovarian Redox Homeostasis and Is Impaired in Polycystic Ovary Syndrome
Experiments in ratsPolycystic ovary syndrome
Aging Cell
Astrocyte Senescence Impairs Synaptogenesis due to Thrombospondin-1 Loss
Experiments in miceCellular senescence