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Thiostrepton

Intervention

1 paper2 findings

PubChem

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Chinese Academy of Medical Sciences Initiative for Innovative Medicine and 2 more
  • Humans1

Outcomes

2

Immunotherapy response

upin mice1

1 study

  1. Thiostrepton improves immunotherapy response in mice.

    “Inhibiting FOXM1 pharmacologically with thiostrepton produced tumor-suppressive effects and improved immunotherapy responses in a Lewis lung carcinoma mouse model.”

    AnimalsLewis lung carcinoma mouse model

    Deciphering the predictive value of senescence-related signature in lung adenocarcinoma: Implications for antitumor immunity and immunotherapy efficacy

    Heliyon8 Aug 2024

Tumor growth

downin mice1

1 study

  1. Thiostrepton decreases tumor growth in mice.

    “Inhibiting FOXM1 pharmacologically with thiostrepton produced tumor-suppressive effects and improved immunotherapy responses in a Lewis lung carcinoma mouse model.”

    AnimalsLewis lung carcinoma mouse model

    Deciphering the predictive value of senescence-related signature in lung adenocarcinoma: Implications for antitumor immunity and immunotherapy efficacy

    Heliyon8 Aug 2024

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