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Tetramethylpyrazine

Intervention

1 paper4 findings

PubChem 14296ChEBI 133246MeSH C017953

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: Hebei North University
  • Cells1

Outcomes

4

Stem cell differentiation

upin rat cells1

1 study

  1. Tetramethylpyrazine increases stem cell differentiation in rat cells.

    “40-50 mg/l TMP treatment may facilitate the neuronal differentiation of bMSCs”

    Cells40-50 mg/l4 days

    Anti-aging effects exerted by Tetramethylpyrazine enhances self-renewal and neuronal differentiation of rat bMSCs by suppressing NF-kB signaling

    Bioscience reports25 Jun 2019

More on Stem cell differentiation

Cell viability

upin rat cells1

1 study

  1. Tetramethylpyrazine increases cell viability in rat cells.

    “treatment with 30-50 mg/l TMP for 4 days significantly increased cell viability”

    Cells4 days

    Anti-aging effects exerted by Tetramethylpyrazine enhances self-renewal and neuronal differentiation of rat bMSCs by suppressing NF-kB signaling

    Bioscience reports25 Jun 2019

NF-κB signalling

downin rat cells1

1 study

  1. Tetramethylpyrazine inhibits NF-κB signalling in rat cells.

    “alleviated senescence by suppressing NF-κB signaling”

    Cells4 days

    Anti-aging effects exerted by Tetramethylpyrazine enhances self-renewal and neuronal differentiation of rat bMSCs by suppressing NF-kB signaling

    Bioscience reports25 Jun 2019

More on NF-κB signalling

Cellular senescence

downin rat cells1

1 study

  1. Tetramethylpyrazine decreases cellular senescence in rat cells.

    “treatment with 30-50 mg/l TMP for 4 days significantly increased cell viability, alleviated senescence by suppressing NF-κB signaling”

    Cells4 days

    Anti-aging effects exerted by Tetramethylpyrazine enhances self-renewal and neuronal differentiation of rat bMSCs by suppressing NF-kB signaling

    Bioscience reports25 Jun 2019

More on Cellular senescence

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