Tert overexpression

Tert overexpression decreases pigmentation in human cells.

“Melanocyte differentiation and pigmentation programs were generally reduced, particularly in clonal cultures.”

Cellsparticularly in clonal cultureslentiviral vectormelanocyte

Lentiviral hTERT Overexpression Extends the Lifespan of Primary Human Epidermal Melanocytes and Reshapes Transcriptional Programs · Biomolecules · 27 Aug 2026

Tert overexpression extends lifespan in human cells (>10 passages).

“hTERT overexpression extended melanocyte culture lifespan by more than 10 passages.”

Cellslentiviral vectormelanocyte

Lentiviral hTERT Overexpression Extends the Lifespan of Primary Human Epidermal Melanocytes and Reshapes Transcriptional Programs · Biomolecules · 27 Aug 2026