Tat-frataxin

1. Tat-frataxin decreases abnormal mitochondrial proliferation in mice.

   “reversed abnormal mitochondrial proliferation and ultrastructure in heart”

   Animalsin mice with a conditional loss of FXNheart

   A TAT-frataxin fusion protein increases lifespan and cardiac function in a conditional Friedreich's ataxia mouse model

   Human molecular genetics·23 Nov 2011

1. Tat-frataxin increases aconitase activity in mice.

   “increased activity of aconitase”

   Animalsin mice with a conditional loss of FXNheart

   A TAT-frataxin fusion protein increases lifespan and cardiac function in a conditional Friedreich's ataxia mouse model

   Human molecular genetics·23 Nov 2011

More on Aconitase activity

1. Tat-frataxin improves cardiac output in mice.

   “increased their mean heart rate and cardiac output”

   Animalsin mice with a conditional loss of FXNheart

   A TAT-frataxin fusion protein increases lifespan and cardiac function in a conditional Friedreich's ataxia mouse model

   Human molecular genetics·23 Nov 2011

1. Tat-frataxin extends lifespan in mice (+53% mean lifespan).

   “increased their growth velocity and mean lifespan by 53%”

   Animalsin mice with a conditional loss of FXN

   A TAT-frataxin fusion protein increases lifespan and cardiac function in a conditional Friedreich's ataxia mouse model

   Human molecular genetics·23 Nov 2011

1. Tat-frataxin decreases CASPASE-3 activation in human cells.

   “reduced caspase-3 activation in response to an exogenous iron-oxidant stress”

   Cellsin response to an exogenous iron-oxidant stressfibroblasts

   A TAT-frataxin fusion protein increases lifespan and cardiac function in a conditional Friedreich's ataxia mouse model

   Human molecular genetics·23 Nov 2011

More on CASPASE-3 activation