AgingResearch.NewsJoin free

Targeting the CXCL2-CXCR2 axis

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: National Key Research and Development Program of China
  • Animals1

Outcomes

2

Neutrophil migration

downin mice1

1 study

  1. Targeting the CXCL2-CXCR2 axis decreases neutrophil migration in mice.

    “Targeting the CXCL2-CXCR2 axis limited the neutrophils migration toward the liver”

    Animalsage-related liver injuryliver

    Single-cell immune profiling of mouse liver aging reveals Cxcl2+ macrophages recruit neutrophils to aggravate liver injury

    Hepatology (Baltimore, Md.)Sep 9, 2023

Liver injury

downin mice1

1 study

  1. Targeting the CXCL2-CXCR2 axis decreases liver injury in mice.

    “Targeting the CXCL2-CXCR2 axis limited the neutrophils migration toward the liver and attenuated age-related liver injury.”

    Animalsage-related liver injuryliver

    Single-cell immune profiling of mouse liver aging reveals Cxcl2+ macrophages recruit neutrophils to aggravate liver injury

    Hepatology (Baltimore, Md.)Sep 9, 2023

Latest

Related