Symptomatic herpes virus infection

Symptomatic herpes virus infection has been studied in 1 paper since 2022: 1 observational study in people. The newest paper, Aug 20, 2022: “Herpes Viruses in the Baltimore Longitudinal Study of Aging: Associations With Brain Volumes, Cognitive Performance, and Plasma Biomarkers”.

Exposure

1 paper studies it3 findingsUpdated

“Having a sHHV diagnosis (N = 119) was associated with longitudinal reductions in white matter volume (annual additional rate of change -0.34 cm3/y; p = 0.035)”
Herpes Viruses in the Baltimore Longitudinal Study of Aging: Associations With Brain Volumes, Cognitive Performance, and Plasma BiomarkersNeurology2022doi:10.1212/wnl.0000000000201036

None of its findings points the other way.

  • 1 lab in 1 country
  • Funders: National Institute on Aging and 2 more
  • Humans1

What did studies of Symptomatic herpes virus infection find?

3

Studies of Symptomatic herpes virus infection measured 3 outcomes; the most studied are GFAP (1 study), attention (1) and white matter volume (1).

GFAP

upin humans1

1 study
  1. Symptomatic herpes virus infection increases GFAP in humans.

    “In addition, sHHV diagnosis was associated with elevated plasma GFAP, but not related to Aβ42/40 and NfL levels.”

    Humansplasma54.8% females

    Herpes Viruses in the Baltimore Longitudinal Study of Aging: Associations With Brain Volumes, Cognitive Performance, and Plasma Biomarkers

    Neurology

More on GFAP

Attention

downin humans1

1 study
  1. Symptomatic herpes virus infection impairs attention in humans (-0.01 Z-score/year, p = 0.008).

    “sHHV diagnosis was associated with accelerated longitudinal declines in attention (annual additional rate of change -0.01 Z-score/year; p = 0.008).”

    Humanslongitudinal cohort54.8% females

    Herpes Viruses in the Baltimore Longitudinal Study of Aging: Associations With Brain Volumes, Cognitive Performance, and Plasma Biomarkers

    Neurology

White matter volume

downin humans1

1 study
  1. Symptomatic herpes virus infection decreases white matter volume in humans (-0.34 cm3/y, p = 0.035).

    “Having a sHHV diagnosis (N = 119) was associated with longitudinal reductions in white matter volume (annual additional rate of change -0.34 cm3/y; p = 0.035)”

    Humanslongitudinal cohortbrain54.8% females

    Herpes Viruses in the Baltimore Longitudinal Study of Aging: Associations With Brain Volumes, Cognitive Performance, and Plasma Biomarkers

    Neurology

More on White matter volume

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