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Sulfasalazine

Intervention

2 papers3 findings

PubChem 5339ChEBI 9334MeSH D012460

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Ministry of SMEs and Startups and 1 more
  • Humans1
  • In silico1

Outcomes

3

Total psoas index

upin humans1

1 study

  1. Sulfasalazine increases total psoas index in humans.

    “Clinical data from patients with IBD revealed that those treated with sulfasalazine had a significantly higher TPI (total psoas index), used as a muscle mass marker”

    Humansin patients with IBD

    Therapeutic potential of sulfasalazine for sarcopenia: Insights from mouse models and clinical data

    Experimental gerontology1 Sep 2025

More on Total psoas index

Muscle loss

downin mice1

1 study

  1. Sulfasalazine decreases muscle loss in mice.

    “sulfasalazine not only enhanced muscle strength and function but also mitigated muscle loss.”

    Animalsin mouse models of muscle atrophy

    Therapeutic potential of sulfasalazine for sarcopenia: Insights from mouse models and clinical data

    Experimental gerontology1 Sep 2025

Muscle strength

upin mice1

1 study

  1. Sulfasalazine improves muscle strength in mice.

    “In mouse models of muscle atrophy, sulfasalazine not only enhanced muscle strength and function but also mitigated muscle loss.”

    Animalsin mouse models of muscle atrophy

    Therapeutic potential of sulfasalazine for sarcopenia: Insights from mouse models and clinical data

    Experimental gerontology1 Sep 2025

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