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Streptococcus pneumoniae

Streptococcus pneumoniae has been studied in 1 paper since 2024: 1 observational study in people. The newest paper, Jun 29, 2024: “Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adults”.

Intervention

1 paper studies it5 findingsUpdated

MeSH

“older adults did not show recruitment of monocytes into the nasal mucosa following nasal colonization”
Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adultsMucosal immunology2024doi:10.1016/j.mucimm.2024.06.010

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 2 independent labs in 2 countries
  • Funders: Japan Agency for Medical Research and Development and others
  • 3 of 5 findings with company ties
  • Humans1

What did studies of Streptococcus pneumoniae find?

2

Studies of Streptococcus pneumoniae measured 2 outcomes; the most studied are monocytes (1 study) and CXCL9 (1).

Monocytes

no changein humans1

1 study

  1. Streptococcus pneumoniae has no effect on monocytes in humans.

    “older adults did not show recruitment of monocytes into the nasal mucosa following nasal colonization”

    Human trialin older adults challenged with pneumococcusnasal mucosa

    Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adults

    Mucosal immunology

More on Monocytes

CXCL9

upin humans1

1 study

  1. Streptococcus pneumoniae increases CXCL9 in humans.

    “elevated levels of CXCL9 and CXCL10”

    Human trialin older adults susceptible to colonizationnasal mucosa

    Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adults

    Mucosal immunology

More on CXCL9

What is Streptococcus pneumoniae linked with?

3

Studies link Streptococcus pneumoniae with 3 measures, most often complement system (1 study), inflammation (1) and mortality (1).

Complement system

upin mice1

1 study

  1. Streptococcus pneumoniae is associated with complement system in mice.

    “enrichment of complement and coagulation cascades, and phagocytic pathways”

    Animalsplasma24 h

    Real-time near-infrared imaging distinguishes nasopharyngeal colonization from aspiration of Streptococcus pneumoniae and identifies aspiration as a trigger of severe disease

    bioRxivPreprint

More on Complement system

Inflammation

upin mice1

1 study

  1. Streptococcus pneumoniae is associated with inflammation in mice.

    “early aspiration in aged mice was associated with the activation of inflammatory and hematopoietic programs, enrichment of complement and coagulation cascades”

    Animalsblood24 h

    Real-time near-infrared imaging distinguishes nasopharyngeal colonization from aspiration of Streptococcus pneumoniae and identifies aspiration as a trigger of severe disease

    bioRxivPreprint

More on Inflammation

Mortality

upin mice1

1 study

  1. Streptococcus pneumoniae raises the risk of mortality in mice (hazard ratio = 7.9).

    “Kaplan-Meier analysis revealed markedly higher mortality in the aspiration group in both young (hazard ratio = 7.9) and aged (hazard ratio = 8.4) mice”

    Animals

    Real-time near-infrared imaging distinguishes nasopharyngeal colonization from aspiration of Streptococcus pneumoniae and identifies aspiration as a trigger of severe disease

    bioRxivPreprint

Funding

11 grants since 2016

National Institute of Allergy and Infectious DiseasesUS$4.2mNational Institute on AgingUS$3mGouvernement du Canada | Canadian Institutes of Health ResearchCA$220k

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