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STAT3 inhibition

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 2 countries
  • Funders: European Commission and 4 more
  • Animals1

Outcomes

3

Transcription of autophagy-related genes

upin mouse cells1

1 study

  1. STAT3 inhibition increases transcription of autophagy-related genes in mouse cells.

    “STAT3 inhibition could activate autophagy at the nuclear level, by promoting transcription of autophagy-related genes”

    Cellsin aged MuSCs

    STAT3 inhibition recovers regeneration of aged muscles by restoring autophagy in muscle stem cells

    Life science alliance6 Jun 2024

Muscle regeneration

upin mice1

1 study

  1. STAT3 inhibition improves muscle regeneration in mice.

    “recovering MuSC ability to promote muscle regeneration in geriatric mice.”

    Animals

    STAT3 inhibition recovers regeneration of aged muscles by restoring autophagy in muscle stem cells

    Life science alliance6 Jun 2024

Autophagy

upin mice1

1 study

  1. STAT3 inhibition increases autophagy in mice.

    “STAT3 inhibition restores the autophagic process in aged MuSCs, thereby recovering MuSC ability to promote muscle regeneration in geriatric mice.”

    Animals

    STAT3 inhibition recovers regeneration of aged muscles by restoring autophagy in muscle stem cells

    Life science alliance6 Jun 2024

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