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Splenectomy

Intervention

3 papers3 findings

MeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funder: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
  • Animals3

Outcomes

3

Erythrocyte survival

upin animals1

1 study

  1. Splenectomy increases erythrocyte survival.

    “prolonged erythrocyte survival followed splenectomy.”

    Animalserythrocyte

    Editorial: Red cell ageing and death

    Vox sanguinis1 Jan 1976

Humoral immune competence

downin mice1

1 study

  1. Splenectomy impairs humoral immune competence in mice.

    “Thus, thymectomy, splenectomy, and sublethal X-irradiation produced lasting immunodepression”

    Animals

    The late effects of selected immunosuppressants on immunocompetence, disease incidence, and mean life-span. I. Humoral immune activity

    Mechanisms of ageing and development1 Jan 1975

Survival

no changein mice1

1 study

  1. Splenectomy has no effect on survival in mice.

    “Thymectomy, splenectomy or cortisone treatment did not alter survival.”

    Animals

    The late effects of selected immunosuppressants on immunocompetence, disease incidence, and mean life-span. III. Disease incidence and life expectancy

    Mechanisms of ageing and development1 Jan 1975

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