Sphingolipid synthesis inhibition

Intervention

1 paper3 findings

  • 1 lab in 1 country
  • Funders: École Polytechnique Fédérale de Lausanne and others
  • Animals1

Outcomes

3

Myogenic potential

upin mice1

1 study
  1. Sphingolipid synthesis inhibition increases myogenic potential in mice.

    “Inhibition of sphingolipid synthesis confers increased myogenic potential”

    Animals

    Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia

    Nature agingDec 16, 2022

Strength and exercise capacity

upin mice1

1 study
  1. Sphingolipid synthesis inhibition improves strength and exercise capacity in mice.

    “both genetic and pharmacological inhibition of sphingolipid synthesis prevent age-related decline in muscle mass while enhancing strength and exercise capacity.”

    Animalsduring aging; genetic and pharmacological inhibition

    Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia

    Nature agingDec 16, 2022

Muscle mass

upin mice1

1 study
  1. Sphingolipid synthesis inhibition increases muscle mass in mice.

    “both genetic and pharmacological inhibition of sphingolipid synthesis prevent age-related decline in muscle mass”

    Animalsduring aging; genetic and pharmacological inhibitionskeletal muscle

    Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia

    Nature agingDec 16, 2022

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