Sphingolipid synthesis inhibition
1 paper3 findings
- 1 lab in 1 country
- Funders: École Polytechnique Fédérale de Lausanne and others
- Animals1
Outcomes
3Myogenic potential
upin mice1
1 study
Myogenic potential
upin mice1
Sphingolipid synthesis inhibition increases myogenic potential in mice.
“Inhibition of sphingolipid synthesis confers increased myogenic potential”
Animals
Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia
Nature agingDec 16, 2022
Strength and exercise capacity
upin mice1
1 study
Strength and exercise capacity
upin mice1
Sphingolipid synthesis inhibition improves strength and exercise capacity in mice.
“both genetic and pharmacological inhibition of sphingolipid synthesis prevent age-related decline in muscle mass while enhancing strength and exercise capacity.”
Animalsduring aging; genetic and pharmacological inhibition
Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia
Nature agingDec 16, 2022
Muscle mass
upin mice1
1 study
Muscle mass
upin mice1
Sphingolipid synthesis inhibition increases muscle mass in mice.
“both genetic and pharmacological inhibition of sphingolipid synthesis prevent age-related decline in muscle mass”
Animalsduring aging; genetic and pharmacological inhibitionskeletal muscle
Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia
Nature agingDec 16, 2022