Sparc

Sparc has been studied in 2 papers since 2016: none in people yet, 1 in animals, 1 review. The research so far is in animals. The newest paper, May 26, 2022: “Genetic Expression between Ageing and Exercise: Secreted Protein Acidic and Rich in Cysteine as a Potential "Exercise Substitute" Antiageing Therapy”.

2 papers study it1 findingUpdated May 26, 2022

1 lab in 1 country

Funders: American Heart Association and 3 more

Animals1

What did studies of Sparc find?

1

Studies of Sparc measured 1 outcome; the most studied are collagen I secretion (1 study).

Collagen I secretion

upin mouse cells1

1 study

Sparc increases collagen I secretion in mouse cells.
“SPARC treatment increased secretion of collagen I and ADAMTS1 (both the 110-kDa latent and 87-kDa active forms) into the conditioned media”
Cellscardiac fibroblast
Increased ADAMTS1 mediates SPARC-dependent collagen deposition in the aging myocardium
American journal of physiology. Endocrinology and metabolismMay 3, 2016

Latest

GenesJun 25

Genetic Expression between Ageing and Exercise: Secreted Protein Acidic and Rich in Cysteine as a Potential "Exercise Substitute" Antiageing Therapy

American Journal of Physiology Endocrinology and MetabolismMay 5

Increased ADAMTS1 mediates SPARC-dependent collagen deposition in the aging myocardium

Experiments in miceMechanisms