Myocardial collagen content

Age is associated with myocardial collagen content in mice.

“Collagen content, determined by picrosirius red staining, increased in an age-dependent manner in WT but not in Null mice.”

Animalswild-type mice; absent in SPARC-null micemyocardium

Increased ADAMTS1 mediates SPARC-dependent collagen deposition in the aging myocardium

American journal of physiology. Endocrinology and metabolism·May 3, 2016