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Sorbus alnifolia

Sorbus alnifolia has been studied in 1 paper since 2017: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Dec 1, 2017: “Sorbus alnifolia protects dopaminergic neurodegeneration in Caenorhabditis elegans”.

Intervention

1 paper studies it5 findingsUpdated

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: National Institute of General Medical Sciences
  • Model organisms1

What did studies of Sorbus alnifolia find?

5

Studies of Sorbus alnifolia measured 5 outcomes; the most studied are alpha-synuclein aggregation (1 study), lifespan (1) and food-sensing behavior (1).

Alpha-synuclein aggregation

no changein worms1

1 study

  1. Sorbus alnifolia has no effect on alpha-synuclein aggregation in worms.

    “However, MESA failed to alter α-synuclein aggregation.”

    Model organisms

    Sorbus alnifolia protects dopaminergic neurodegeneration in Caenorhabditis elegans

    Pharmaceutical biology

More on Alpha-synuclein aggregation

Lifespan

upin worms1+26% average lifespan

1 study

  1. Sorbus alnifolia extends lifespan in worms (+25.6% average lifespan).

    “MESA also prolonged the average lifespan by 25.6%.”

    Model organisms

    Sorbus alnifolia protects dopaminergic neurodegeneration in Caenorhabditis elegans

    Pharmaceutical biology

Food-sensing behavior

upin worms1+58%

1 study

  1. Sorbus alnifolia improves food-sensing behavior in worms (+58.4%).

    “food-sensing functions were increased 58.4% by MESA in the DA neuron degraded worms.”

    Model organismsin DA neuron degraded worms

    Sorbus alnifolia protects dopaminergic neurodegeneration in Caenorhabditis elegans

    Pharmaceutical biology

Dopaminergic neurodegeneration

downin worms1

1 study

  1. Sorbus alnifolia protects against dopaminergic neurodegeneration in worms.

    “In C. elegans, MESA provided protection against chemically and genetically-induced DA neurodegeneration, respectively.”

    Model organisms

    Sorbus alnifolia protects dopaminergic neurodegeneration in Caenorhabditis elegans

    Pharmaceutical biology

Viability

upin worms1

1 study

  1. Sorbus alnifolia increases viability in worms (85.8% viability in PC12 cells, 54.9% in C. elegans).

    “MESA restored MPP+-induced loss of viability in both PC12 cells and C. elegans (85.8% and 54.9%, respectively).”

    Model organismsMPP+-treated

    Sorbus alnifolia protects dopaminergic neurodegeneration in Caenorhabditis elegans

    Pharmaceutical biology

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