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Social determinants of health burden

Social determinants of health burden has been studied in 4 papers since 2025: 4 observational studies in people; 2 in the past year. The newest story, Nov 7, 2026: “High social disadvantage linked to heart risk like mild artery calcium”.

Exposure

4 papers study it7 findingsUpdated

2 new papers in 30 daysSee all 4 papers on social determinants of health burden

At a glance

The findings reach people, from one lab or study. 4 independent labs in 2 countries.

“each 1-point increment in SDOH score was associated with 4% greater odds of being in Stage 1 (95% CI: 1.01-1.07)”
Association Between Social Determinants of Health and Cardiovascular-Kidney-Metabolic Syndrome in U.S. Adults From the National Health and Nutrition Examination SurveyAHA Scientific Sessions 2025 abstract2025doi:10.1161/circ.152.suppl_3.4362728

None of its findings points the other way.

Humans: a single group. Cells, worms or flies and mice: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 4 independent labs in 2 countries
  • Funder: Peking University First Hospital
  • Humans4

What is social determinants of health burden linked with?

7

Studies link social determinants of health burden with 7 measures, among them incident cardiovascular disease, mortality and cardiovascular disease.

Incident cardiovascular disease

upin humans1

1 study

  1. Social determinants of health burden is associated with incident cardiovascular disease in humans (CKM stages 1/2 without coronary artery calcium or clinical cardiovascular disease) (Q1: 1.72 (95% CI 0.85–3.50); Q2: 2.60 (1.45–4.66); Q3: 3.09 (1.73–5.49); Q4: 3.77 (2.18–6.53) events per 1,000 person-years).

    “Within CKM 1/2, SDOH burden produced a graded increase in CVD incidence rates”

    HumansCKM stages 1/2 without coronary artery calcium or clinical cardiovascular diseaseSDOH burden quartiles Q1–Q410 years

    High social disadvantage linked to heart risk like mild artery calcium

    AHA Scientific Sessions 2026 abstract

More on Incident cardiovascular disease

Mortality

upin humans1HR 1.2

1 study

  1. Social determinants of health burden is associated with mortality in humans (Chinese population across cardiovascular-kidney-metabolic stages 0-4) (HR 1.20, 95% CI 1.14–1.27 per 1-point increase in SDOH score).

    “each 1-point increase in the SDOH score was associated with a 20% elevated risk of all-cause mortality”

    HumansChinese population across cardiovascular-kidney-metabolic stages 0-4Each 1-point increase in SDOH scoreMedian follow-up of 9 years

    Association of social determinants of health and all-cause mortality among individuals across cardiovascular-kidney-metabolic stages 0-4: a nationwide prospective cohort study

    Journal of diabetes and metabolic disorders

Cardiovascular disease

upin humans1OR 1.28

1 study

  1. Social determinants of health burden is linked with a higher risk of cardiovascular disease in humans (compared to Stage 0) (OR 1.28 (95% CI: 1.24-1.32)).

    “28% greater odds for Stage 4 (95% CI: 1.24-1.32)”

    Humanscompared to Stage 0each 1-point increment50.7% malesn = 13,678

    Association Between Social Determinants of Health and Cardiovascular-Kidney-Metabolic Syndrome in U.S. Adults From the National Health and Nutrition Examination Survey

    AHA Scientific Sessions 2025 abstract

More on Cardiovascular disease

Cardiovascular-kidney-metabolic syndrome stage 3

upin humans1

1 study

  1. Social determinants of health burden is linked with a higher risk of cardiovascular-kidney-metabolic syndrome stage 3 in humans (compared to Stage 0).

    “23% greater odds for Stage 3 (95% CI: 1.18-1.28)”

    Humanscompared to Stage 0each 1-point increment50.7% malesn = 13,678

    Association Between Social Determinants of Health and Cardiovascular-Kidney-Metabolic Syndrome in U.S. Adults From the National Health and Nutrition Examination Survey

    AHA Scientific Sessions 2025 abstract

More on Cardiovascular-kidney-metabolic syndrome stage 3

Cardiovascular-kidney-metabolic syndrome stage 2

upin humans1

1 study

  1. Social determinants of health burden is linked with a higher risk of cardiovascular-kidney-metabolic syndrome stage 2 in humans (compared to Stage 0).

    “10% greater odds for Stage 2 (95% CI: 1.07-1.13)”

    Humanscompared to Stage 0each 1-point increment50.7% malesn = 13,678

    Association Between Social Determinants of Health and Cardiovascular-Kidney-Metabolic Syndrome in U.S. Adults From the National Health and Nutrition Examination Survey

    AHA Scientific Sessions 2025 abstract

More on Cardiovascular-kidney-metabolic syndrome stage 2

Excess adiposity

upin humans1

1 study

  1. Social determinants of health burden is linked with a higher risk of excess adiposity in humans (compared to Stage 0).

    “each 1-point increment in SDOH score was associated with 4% greater odds of being in Stage 1 (95% CI: 1.01-1.07)”

    Humanscompared to Stage 0each 1-point increment50.7% malesn = 13,678

    Association Between Social Determinants of Health and Cardiovascular-Kidney-Metabolic Syndrome in U.S. Adults From the National Health and Nutrition Examination Survey

    AHA Scientific Sessions 2025 abstract

Diabetes and kidney disease comorbidity

upin humans1HR 1.24

1 study

  1. Social determinants of health burden is linked with a higher risk of diabetes and kidney disease comorbidity in humans (HR = 1.24, 95% CI = 1.01-1.52).

    “High SDOH burden was associated with an increased risk of comorbidity (HR = 1.24, 95% CI = 1.01-1.52).”

    Humans

    Trends, Social Determinants, and Lifestyle Factors Associated With Comorbidity of Diabetes and Kidney Diseases Among Chinese Adults Aged ≥ 45 Years

    Journal of diabetes

More on Diabetes and kidney disease comorbidity

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 1Nov 2026: 12 papers in 12 months
AHA Scientific Sessions 2026 Abstract

High social disadvantage linked to heart risk like mild artery calcium

Cardiovascular event rates were 3.77 per 1,000 person-years with high social disadvantage and no artery calcium, versus 3.12 with mild calcium and high disadvantage.Cardiovascular event rates were 3.77 per 1,000 person-years with high social disadvantage and no artery calcium, versus 3.12 with mild calcium and high disadvantage.

Cohort · 2,901 peoplePopulations
Paper

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