Sleep medication

3 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries
0 on aging of 1 trial

Humans3

Associations

Cognitive function

downin humans1

1 study

Sleep medication is associated with cognitive function in humans (B = -0.91, 95% CI [-1.71, -0.10], p < 0.05).
“Sleep medication use was associated with poorer sleep quality (B = 4.42, 95% CI [3.29, 5.55], p < 0.01) and lower cognitive performance (B = -0.91, 95% CI [-1.71, -0.10], p < 0.05).”
Humansn = 151
Chronotype, sleep quality, and functional health in active older adults: A cross-sectional study
Chronobiology international25 Feb 2026

Sleep quality

downin humans1

1 study

Sleep medication is associated with sleep quality in humans (B = 4.42, 95% CI [3.29, 5.55], p < 0.01).
“Sleep medication use was associated with poorer sleep quality (B = 4.42, 95% CI [3.29, 5.55], p < 0.01)”
Humansn = 151
Chronotype, sleep quality, and functional health in active older adults: A cross-sectional study
Chronobiology international25 Feb 2026

Disability

upin humans1

1 study

Sleep medication is associated with disability in humans (0.19 per year (SE = .02, p < .001)).
“and 0.19 (SE = .02, p < .001) every year, respectively, adjusting for covariates.”
Humans5 yearsn = 6,722
Late-life Disability May Increase with More Frequent Insomnia Symptoms and Sleep Medications Use Over Time
GSA 2025 abstract31 Dec 2025