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Treadmill exercise + skin cooling

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: Kao Corporation
  • 2 of 2 findings with company ties
  • Animals1

Outcomes

2

C-boutons

upin mice1

1 study

  1. Treadmill exercise + skin cooling increases C-boutons in mice.

    “exercise combined with TRPM8-mediated SC during reloading restored C-bouton density”

    Animalsduring reloading after hindlimb unloading

    Spinal motor neuron plasticity after hindlimb unloading in aged mice and its modulation by exercise with TRPM8-mediated cutaneous stimulation

    Experimental gerontology17 Oct 2025

More on C-boutons

Motor function

upin mice1

1 study

  1. Treadmill exercise + skin cooling improves motor function in mice.

    “exercise combined with TRPM8-mediated SC during reloading restored C-bouton density and improved motor function in aged mice”

    Animalsduring reloading after hindlimb unloading

    Spinal motor neuron plasticity after hindlimb unloading in aged mice and its modulation by exercise with TRPM8-mediated cutaneous stimulation

    Experimental gerontology17 Oct 2025

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