Silica nanoparticles

2 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Humans1
Cells1

Outcomes

Sit-to-stand test

upin humans1

1 study

Silica nanoparticles increase sit-to-stand test in humans (В = 0.91).
“and sit-to-stand test (В = 0.91; р = 0.011) were explored.”
Humansoccupational chronic obstructive pulmonary disease
Peculiarities of sarcopenia in occupational chronic obstructive pulmonary disease in conditions of exposure of industrial aerosols containing nanoparticles
Terapevticheskii arkhiv17 Mar 2026

Appendicular fat-free mass index

downin humans1

1 study

Silica nanoparticles decrease appendicular fat-free mass index in humans (В = -1.05).
“appendicular fat-free mass index (В = -1.05; р = 0.001)”
Humansoccupational chronic obstructive pulmonary disease
Peculiarities of sarcopenia in occupational chronic obstructive pulmonary disease in conditions of exposure of industrial aerosols containing nanoparticles
Terapevticheskii arkhiv17 Mar 2026

More on Appendicular fat-free mass index

Quadriceps cross-sectional area

downin humans1

1 study

Silica nanoparticles decrease quadriceps cross-sectional area in humans (В = -0.95).
“associations of silica nanoparticles with quadriceps cross-sectional area (В = -0.95; р = 0.009)”
Humansoccupational chronic obstructive pulmonary disease
Peculiarities of sarcopenia in occupational chronic obstructive pulmonary disease in conditions of exposure of industrial aerosols containing nanoparticles
Terapevticheskii arkhiv17 Mar 2026

Associations

Sarcopenia

upin humans1

1 study

Silica nanoparticles raise the risk of sarcopenia in humans (47.2% vs 35.4% and 30.0%).
“Sarcopenia rate was 26 (47.2%) in COPD due to aerosols containing silica nanoparticles, 17 (35.4%) in COPD due to aerosols containing metal nanoparticles and 15 (30.0%) in control group; p = 0.015.”
Humansoccupational chronic obstructive pulmonary disease
Peculiarities of sarcopenia in occupational chronic obstructive pulmonary disease in conditions of exposure of industrial aerosols containing nanoparticles
Terapevticheskii arkhiv17 Mar 2026