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Senescent stromal cell depletion

Exposure

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Alvin J. Siteman Cancer Center and others
  • Animals1

Outcomes

3

Responsiveness to chemotherapy

upin mice1

1 study

  1. Senescent stromal cell depletion increases responsiveness to chemotherapy in mice.

    “Depletion of senescent stromal cells in genetic and pharmacologic PDAC models relieved immune suppression by macrophages, delayed tumor progression, and increased responsiveness to chemotherapy.”

    Animalsgenetic and pharmacologic pancreatic ductal adenocarcinoma models

    Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer

    Cancer discovery1 Jul 2024

Pancreatic ductal adenocarcinoma progression

downin mice1

1 study

  1. Senescent stromal cell depletion decreases pancreatic ductal adenocarcinoma progression in mice.

    “Depletion of senescent stromal cells in genetic and pharmacologic PDAC models relieved immune suppression by macrophages, delayed tumor progression, and increased responsiveness to chemotherapy.”

    Animalsgenetic and pharmacologic pancreatic ductal adenocarcinoma models

    Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer

    Cancer discovery1 Jul 2024

Macrophage-mediated immune suppression

downin mice1

1 study

  1. Senescent stromal cell depletion decreases macrophage-mediated immune suppression in mice.

    “Depletion of senescent stromal cells in genetic and pharmacologic PDAC models relieved immune suppression by macrophages”

    Animalsgenetic and pharmacologic pancreatic ductal adenocarcinoma modelstumor stroma

    Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer

    Cancer discovery1 Jul 2024

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