Senescent fibroblast-conditioned medium

1 paper1 finding

1 lab in 1 country

Funders: Hillman Cancer Center, Medical Center, University of Pittsburgh and 3 more

Cells1

Outcomes

1

Breast cancer cell proliferation

upin human cells1

1 study

Senescent fibroblast-conditioned medium increases breast cancer cell proliferation in human cells.
“conditioned medium derived from senescent lung fibroblasts, which were induced to senesce by I3P treatment, promoted the proliferation of breast cancer cells and their tumorigenic potential.”
Cellsconditioned medium from I3P-induced senescent lung fibroblastsbreast cancer cell
Extracellular ATP drives tryptophan metabolism and aryl hydrocarbon receptor activation to promote cellular senescence
The Journal of biological chemistry27 Apr 2026

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The Journal of Biological Chemistry30 Apr

Extracellular ATP drives tryptophan metabolism and aryl hydrocarbon receptor activation to promote cellular senescence

Experiments in human cellsAmino acid metabolism