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Secretin

Intervention

1 paper3 findings

MeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: U.S. Department of Veterans Affairs
  • Animals1

Outcomes

2

Cellular senescence

downin human cells1downin mice1

1 study

  1. Secretin decreases cellular senescence in human cells.

    “SCT 5-27 treatment of a human biliary PSC cell line decreased proliferation and senescence”

    Cellshuman biliary PSC cell line

    Prolonged administration of a secretin receptor antagonist inhibits biliary senescence and liver fibrosis in Mdr2 -/- mice

    Hepatology (Baltimore, Md.)Feb 18, 2023

  2. Secretin inhibits cellular senescence in mice.

    “Prolonged administration of a secretin receptor antagonist inhibits biliary senescence and liver fibrosis in Mdr2 -/- mice”

    AnimalsMdr2 -/- mice3 monthsmales

    Prolonged administration of a secretin receptor antagonist inhibits biliary senescence and liver fibrosis in Mdr2 -/- mice

    Hepatology (Baltimore, Md.)Feb 18, 2023

More on Cellular senescence

Liver fibrosis

downin mice1

1 study

  1. Secretin inhibits liver fibrosis in mice.

    “Prolonged administration of a secretin receptor antagonist inhibits biliary senescence and liver fibrosis in Mdr2 -/- mice”

    AnimalsMdr2 -/- mice3 monthsmales

    Prolonged administration of a secretin receptor antagonist inhibits biliary senescence and liver fibrosis in Mdr2 -/- mice

    Hepatology (Baltimore, Md.)Feb 18, 2023

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