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iScience·2 Oct

Separable cognitive and motor decline tracked across adult life-span for goal-directed navigation

Cohort study in peopleMechanisms

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Lilly’s retatrutide achieves 18.8% weight loss in obesity and type 2 diabetesTrialsMedical Xpress and 4 more

Human ovaries keep remodeling with increasing inflammation decades after menopause, researchers reportResearchMedical Xpress and 1 more

Rubedo reports RLS-1496 lowers measured skin epigenetic age 2.1 years in atopic dermatitisTrialsLongevity.Technology and 1 more

Trials

Fatigability of Lower Limb Muscle in Older Adults: Protective Effects of Strength Training Exercise in Old Men and WomenResults posted 13 Oct 2026, Marquette University Fisetin for Improving Vascular Function in Older Adults: A Phase II Clinical TrialPhase 2Registered 13 Oct 2026, University of Colorado, Boulder ELITE: Deep Profiling and Algorithmic Polytherapy to Map Individual Response in Healthy AgingPhase 2Registered 13 Oct 2026, Sheba Medical Center

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Mechanisms272 Interventions511 Biomarkers458 Populations631 AI & data166 Industry & policy26

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