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Se-methylselenocysteine

Se-methylselenocysteine has been studied in 2 papers since 2022: none in people yet, 2 in cells. No study of it in people or animals has been published yet. The newest paper, May 26, 2025: “Optimizing Se- methylselenocysteine concentration to enhance glutathione peroxidase 1 expression and mitigate oxidative stress in senescent human fibroblast”.

Intervention

2 papers study it4 findingsUpdated

PubChemChEBI

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: King Saud University and 1 more
  • Cells2

What did studies of Se-methylselenocysteine find?

4

Studies of Se-methylselenocysteine measured 4 outcomes; the most studied are hydrogen peroxide (1 study), GPX1 (1) and glutathione peroxidase 1 activity (1).

Hydrogen peroxide

downin human cells1

1 study

  1. Se-methylselenocysteine decreases hydrogen peroxide in human cells (reductions of approximately 11.5%, 40%, 57%, and 58% in P30 CM3, CM4, CM5, and CM6-incubated cells).

    “hydrogen peroxide levels were significantly reduced in CM3-incubated cells compared to CM1 (p<0.01), reaching the lowest values in CM6 (p<0.001)”

    Cellsin senescent human fibroblastsfibroblast

    Optimizing Se- methylselenocysteine concentration to enhance glutathione peroxidase 1 expression and mitigate oxidative stress in senescent human fibroblast

    Cellular and molecular biology (Noisy-le-Grand, France)

More on Hydrogen peroxide

GPX1

upin human cells1

1 study

  1. Se-methylselenocysteine increases GPX1 in human cells (reached 248.0±18.6% in P30 cells).

    “Similarly, GPx1 expression was markedly upregulated in CM2, CM4, and CM6-incubated cells compared to primary P5 cells (p<0.001)”

    Cellsin senescent human fibroblastsfibroblast

    Optimizing Se- methylselenocysteine concentration to enhance glutathione peroxidase 1 expression and mitigate oxidative stress in senescent human fibroblast

    Cellular and molecular biology (Noisy-le-Grand, France)

More on GPX1

Glutathione peroxidase 1 activity

upin human cells1

1 study

  1. Se-methylselenocysteine increases glutathione peroxidase 1 activity in human cells (up to 250% in P30 cells).

    “the enzyme exhibited significant MSC-dose-dependent elevations in cells cultured in MSC-supplemented media (CM3-CM6) compared to CM1 (p<0.001).”

    Cellsin senescent human fibroblastsfibroblast

    Optimizing Se- methylselenocysteine concentration to enhance glutathione peroxidase 1 expression and mitigate oxidative stress in senescent human fibroblast

    Cellular and molecular biology (Noisy-le-Grand, France)

More on Glutathione peroxidase 1 activity

Oxidative stress and ROS signaling

downin human cells1

1 study

  1. Se-methylselenocysteine decreases oxidative stress and ROS signaling in human cells.

    “organic L-hydroxyselenomethionine and Se-methylselenocysteine are equally more potent at alleviating oxidative stress in senescent cells than inorganic sodium selenite”

    Cellssenescent fibroblastsfibroblasts

    Biochemical and molecular assessment of selenium forms for the alleviation of oxidative stress in senescent human fibroblasts

    General physiology and biophysics

More on Oxidative stress and ROS signaling

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