S-adenosyl-L-homocysteine has been studied in 1 paper since 2022: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Apr 7, 2022: “S-adenosyl-L-homocysteine extends lifespan through methionine restriction effects”.
None of its findings points the other way.
Studies of S-adenosyl-L-homocysteine measured 5 outcomes; the most studied are AMPK signaling (1 study), lifespan (1) and autophagy (1).
AMPK signaling
upin worms1
S-adenosyl-L-homocysteine activates AMPK signaling in worms.
“Furthermore, in Caenorhabditis elegans SAH treatment extends lifespan by activating AMPK and providing benefits of MetR.”
Model organisms
S-adenosyl-L-homocysteine extends lifespan through methionine restriction effects
Aging cell
Lifespan
upin worms1
S-adenosyl-L-homocysteine extends lifespan in worms.
“Furthermore, in Caenorhabditis elegans SAH treatment extends lifespan by activating AMPK and providing benefits of MetR.”
Model organisms
S-adenosyl-L-homocysteine extends lifespan through methionine restriction effects
Aging cell
Autophagy
upin yeast cells1
S-adenosyl-L-homocysteine activates autophagy in yeast cells.
“In yeast, SAH supplementation leads to inhibition of the target of rapamycin complex 1 (TORC1) and activation of autophagy.”
Cells
S-adenosyl-L-homocysteine extends lifespan through methionine restriction effects
Aging cell
mTOR signaling
downin yeast cells1
S-adenosyl-L-homocysteine inhibits mTOR signaling in yeast cells.
“In yeast, SAH supplementation leads to inhibition of the target of rapamycin complex 1 (TORC1) and activation of autophagy.”
Cells
S-adenosyl-L-homocysteine extends lifespan through methionine restriction effects
Aging cell
Methionine
downin yeast cells1
S-adenosyl-L-homocysteine decreases methionine in yeast cells.
“SAH supplementation reduces Met levels and recapitulates many physiological and molecular effects of MetR.”
Cells
S-adenosyl-L-homocysteine extends lifespan through methionine restriction effects
Aging cell
Experiments linked the effect to a brief burst of reactive oxygen molecules and a transporter protein called Ybt1.Experiments linked the effect to a brief burst of reactive oxygen molecules and a transporter protein called Ybt1.