Rubus occidentalis

1. Rubus occidentalis decreases ISC marker gene expression in humans.

   “Finally, the study observes a reduction in ISC marker gene expression in adjacent normal crypts following introduction of BRBs to the human bowel.”

   Human trialadjacent normal cryptsbowel

   Modification of Diet to Reduce the Stemness and Tumorigenicity of Murine and Human Intestinal Cells

   Molecular nutrition & food research·31 Aug 2022

More on ISC marker gene expression

1. Rubus occidentalis decreases self-renewal capacity in human cells.

   “In ex vivo culture BRBs reduce the self-renewal capacity of murine and human Apc deficient organoids.”

   CellsApc deficient

   Modification of Diet to Reduce the Stemness and Tumorigenicity of Murine and Human Intestinal Cells

   Molecular nutrition & food research·31 Aug 2022

1. Rubus occidentalis decreases tumor area in mice.

   “Following Apc ISC deletion, BRB diet extends lifespan and reduces tumor area.”

   Animalsfollowing Apc ISC deletion10%

   Modification of Diet to Reduce the Stemness and Tumorigenicity of Murine and Human Intestinal Cells

   Molecular nutrition & food research·31 Aug 2022

1. Rubus occidentalis extends lifespan in mice.

   “Following Apc ISC deletion, BRB diet extends lifespan and reduces tumor area.”

   Animalsfollowing Apc ISC deletion10%

   Modification of Diet to Reduce the Stemness and Tumorigenicity of Murine and Human Intestinal Cells

   Molecular nutrition & food research·31 Aug 2022