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Reverse dipping

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 2 countries
  • Funder: National Institute on Aging
  • Humans1

Associations

2

Memory functioning

downin humans1

1 study

  1. Reverse dipping is associated with memory functioning in humans (F 2,423 = 3.911, p = 0.021).

    “and with lowered memory scores (F 2,423 = 3.911, p = 0.021).”

    Humansin the presence of hypertension

    White matter hyperintensities mediate the association of nocturnal blood pressure with cognition

    Neurology15 Apr 2020

Periventricular white matter hyperintensities

upin humans1

1 study

  1. Reverse dipping is associated with periventricular white matter hyperintensities in humans (F 2,423 = 3.78, p = 0.024).

    “Reverse dipping in the presence of hypertension was associated with particularly elevated periventricular WMH volume (F 2,423 = 3.78, p = 0.024)”

    Humansin the presence of hypertension

    White matter hyperintensities mediate the association of nocturnal blood pressure with cognition

    Neurology15 Apr 2020

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