Resveratrol + vitamin C

1 paper2 findings

PubChem 445154 PubChem 54670067 ChEBI 27881 ChEBI 29073

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: China Medical University and 2 more

Animals1

Outcomes

Cellular senescence

downin mouse cells1

1 study

Resveratrol + vitamin C decreases cellular senescence in mouse cells.
“Co-treatment with resveratrol (ATM activator) and vitamin C (TET1 activator) rejuvenates late MSCs via the TRIM37/PARP1/DNMT1 pathway”
Cellsco-treatment in late MSCs
TRIM37-PARP1-TET1 axis maintains stemness and prevents osteoporosis by inhibiting DNMT1 alternative splicing via 5hmC regulation
Nature communications16 Dec 2025

Associations

Osteoporosis

downin mice1

1 study

Resveratrol + vitamin C lowers the risk of osteoporosis in mice.
“Co-treatment with resveratrol (ATM activator) and vitamin C (TET1 activator) rejuvenates late MSCs via the TRIM37/PARP1/DNMT1 pathway and alleviates osteoporosis in aged mice.”
Animalsco-treatment
TRIM37-PARP1-TET1 axis maintains stemness and prevents osteoporosis by inhibiting DNMT1 alternative splicing via 5hmC regulation
Nature communications16 Dec 2025