Reducing ribosome abundance

Intervention1 paper2 findings

Outcomes

Meiotic defects

upin flies1

1 study

Reducing ribosome abundance induces meiotic defects in flies.
Model organismsoocytefemales
Declining ribosome function drives reproductive aging in fruit fly and mouse oocytes · bioRxiv · 30 Sep 2026 · Preprint

Developmental competence

downin flies1

1 study

Reducing ribosome abundance impairs developmental competence in flies.
Model organismsoocytefemales
Declining ribosome function drives reproductive aging in fruit fly and mouse oocytes · bioRxiv · 30 Sep 2026 · Preprint

Model organismsPreprint1 Oct

A genetic screen and functional assays show that falling translational capacity causes meiotic and developmental defects during oocyte aging.

bioRxiv · Judson KL et al.