1 paper1 finding
Digit-tip regeneration
upin mice1
Rankl improves digit-tip regeneration in mice.
“CD4 + T-cell-mediated inhibition of regeneration was rescued by supplementation with T regulatory cells or recombinant RANKL, a mediator of osteoclast differentiation.”
AnimalsCD4+ T-cell-mediated inhibition of regenerationrecombinantdigit tip
Some immune cells hindered digit-tip regrowth in mice
NPJ Regenerative medicine13 Oct 2026
1 trialPhase 220 people
National Institute of Arthritis and Musculoskeletal and Skin DiseasesUS$1.3mJapan Society for the Promotion of ScienceJP¥8.5m
Antagonism of RANKL signaling by estrogen in osteoclasts
National Institute of Arthritis and Musculoskeletal and Skin DiseasesUniv of Arkansas for Med ScisUS$432.5k2024–2029
Pathogenesis of senile osteoporosis: regulation of RANKL and RANK expression by DNA methylation
Japan Society for the Promotion of ScienceEhime UniversityJP¥4.2m2022–2025
Pathogenesis of senile osteoporosis: regulation of RANKL expression in aging model
Japan Society for the Promotion of ScienceEhime UniversityJP¥4.3m2019–2022
Cell-transfer experiments in mice lacking lymphoid immune cells found that regulatory immune cells rescued regeneration inhibited by another immune-cell type.Cell-transfer experiments in mice lacking lymphoid immune cells found that regulatory immune cells rescued regeneration inhibited by another immune-cell type.