Quercetin-primed senomorphic small extracellular vesicles in alpha-lipoic acid hydrogel
1 paper4 findings
- 1 lab in 1 country
- Funders: National Natural Science Foundation of China and 1 more
- Animals1
Outcomes
4Cellular senescence
downin rats1
1 study
Cellular senescence
downin rats1
Quercetin-primed senomorphic small extracellular vesicles in alpha-lipoic acid hydrogel decreases cellular senescence in rats.
“attenuating M1 macrophage-driven inflammation and enhancing BMSC resilience to inflammation-exacerbated senescence.”
Animalsinflammatory-senescent microenvironment
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Apr 7, 2026
cGAS–STING signalling
downin rats1
1 study
cGAS–STING signalling
downin rats1
Quercetin-primed senomorphic small extracellular vesicles in alpha-lipoic acid hydrogel inhibits cGAS–STING signalling in rats.
“Sm-sEV/αLA-Gel suppresses cGAS-STING-NF-κB signaling, thereby reducing inflammation and improving BMSC resistance to senescence.”
Animalsinflammatory-senescent microenvironment
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Apr 7, 2026
Mechanical strength
upin rats1
1 study
Mechanical strength
upin rats1
Quercetin-primed senomorphic small extracellular vesicles in alpha-lipoic acid hydrogel improves mechanical strength in rats.
“enhanced bone formation and fibrocartilage maturation, thereby promoting superior BTI integration and mechanical strength.”
Animalsin an osteoporotic rotator cuff repair modelbone-tendon interface
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Apr 7, 2026
Bone-tendon interface integration
upin rats1
1 study
Bone-tendon interface integration
upin rats1
Quercetin-primed senomorphic small extracellular vesicles in alpha-lipoic acid hydrogel improves bone-tendon interface integration in rats.
“Sm-sEV/αLA-Gel enhanced bone formation and fibrocartilage maturation, thereby promoting superior BTI integration and mechanical strength.”
Animalsin an osteoporotic rotator cuff repair modelbone-tendon interface
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Apr 7, 2026