Progranulin

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Animals1

Outcomes

RHOA

downin mouse cells1

1 study

Progranulin inhibits RHOA in mouse cells.
“exogenous PGRN restored neurite extension by inhibiting RhoA activation”
Cellsin LPS-treated HT22 cells
Progranulin deficiency exacerbates postoperative cognitive dysfunction via RhoA-mediated axodendritic impairment in aged mice
Brain research bulletin21 Nov 2025

Latest

1 in 12 months

Brain Research Bulletin24 Nov

Progranulin deficiency exacerbates postoperative cognitive dysfunction via RhoA-mediated axodendritic impairment in aged mice

Experiments in micePostoperative cognitive dysfunction

Paper

Progranulin

Outcomes

Latest

Progranulin deficiency exacerbates postoperative cognitive dysfunction via RhoA-mediated axodendritic impairment in aged mice

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