Pramipexole

1. Pramipexole increases Drd2 expression in mice.

   “ameliorated the downregulation of dopamine D2 receptors in the hippocampus after repeated sevoflurane exposure in aged mice.”

   AnimalsRepeated sevoflurane exposurehippocampusThree consecutive days

   Pramipexole ameliorates cognitive deficits in aged mice after sevoflurane anesthesia by upregulating dopamine D2 receptors in parvalbumin interneuron of the hippocampus

   Experimental neurology·30 Jul 2026

More on Drd2 expression

1. Pramipexole increases gamma oscillations in mice.

   “reversed the reduction in gamma oscillations”

   AnimalsRepeated sevoflurane exposurehippocampusThree consecutive days

   Pramipexole ameliorates cognitive deficits in aged mice after sevoflurane anesthesia by upregulating dopamine D2 receptors in parvalbumin interneuron of the hippocampus

   Experimental neurology·30 Jul 2026

1. Pramipexole increases parvalbumin interneuron activity in mice.

   “rescued the reduction in the activity of PV interneuron”

   AnimalsRepeated sevoflurane exposurehippocampusThree consecutive days

   Pramipexole ameliorates cognitive deficits in aged mice after sevoflurane anesthesia by upregulating dopamine D2 receptors in parvalbumin interneuron of the hippocampus

   Experimental neurology·30 Jul 2026

1. Pramipexole increases Pvalb expression in mice.

   “reversed the downregulation of parvalbumin (PV) expression”

   AnimalsRepeated sevoflurane exposurehippocampusThree consecutive days

   Pramipexole ameliorates cognitive deficits in aged mice after sevoflurane anesthesia by upregulating dopamine D2 receptors in parvalbumin interneuron of the hippocampus

   Experimental neurology·30 Jul 2026

More on Pvalb expression

1. Pramipexole decreases glial cell activation in mice.

   “PPX attenuated glial cell activation”

   AnimalsRepeated sevoflurane exposurehippocampusThree consecutive days

   Pramipexole ameliorates cognitive deficits in aged mice after sevoflurane anesthesia by upregulating dopamine D2 receptors in parvalbumin interneuron of the hippocampus

   Experimental neurology·30 Jul 2026

1. Pramipexole improves memory and cognitive function in mice.

   “thereby ameliorating memory and cognitive deficits.”

   AnimalsRepeated sevoflurane anesthesiaThree consecutive days

   Pramipexole ameliorates cognitive deficits in aged mice after sevoflurane anesthesia by upregulating dopamine D2 receptors in parvalbumin interneuron of the hippocampus

   Experimental neurology·30 Jul 2026