poly-L-lactic acid implants combined with TGF-β1/IL-10 gene-modified bone marrow mesenchymal stem cells

1. poly-L-lactic acid implants combined with TGF-β1/IL-10 gene-modified bone marrow mesenchymal stem cells increase BMP2 and type II collagen expression in rats.

   “accompanied by increased BMP2 and type II collagen (COL-2) expression.”

   Animalscombined treatment of osteoarthritis-related cartilage defects

   3D bioprinted porous PLLA implants with dual gene modified BMSCs for osteoarthritis cartilage repair

   Acta orthopaedica Belgica·8 Oct 2026

More on BMP2 and type II collagen expression

1. poly-L-lactic acid implants combined with TGF-β1/IL-10 gene-modified bone marrow mesenchymal stem cells improve cartilage regeneration and subchondral bone repair in rats.

   “In vivo, the combined treatment group displayed superior cartilage regeneration and subchondral bone repair compared with controls”

   Animalsosteoarthritis-related cartilage defects; compared with controls3D-bioprinted spherical porous implants combined with dual-gene-transduced BMSCscartilage and subchondral bone

   3D bioprinted porous PLLA implants with dual gene modified BMSCs for osteoarthritis cartilage repair

   Acta orthopaedica Belgica·8 Oct 2026