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Pkm2+ mesenchymal stem cell-derived apoptotic vesicles

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Guangdong Provincial Pearl River Talents Program and 2 more
  • Animals1

Outcomes

2

Cellular senescence

downin mice1

1 study

  1. Pkm2+ mesenchymal stem cell-derived apoptotic vesicles decrease cellular senescence in mice.

    “Systemic administration of PKM2+ mesenchymal stem cell-derived apoVs (MSC-apoVs) effectively rescues apoptotic resistance, eliminates senescent cells, and mitigates CP phenotypes.”

    AnimalsCP mice

    PKM2⁺ apoptotic vesicle-mediated systemic senolytics ameliorate chronic periodontitis

    Bioactive materials4 Jul 2025

More on Cellular senescence

Chronic periodontitis

downin mice1

1 study

  1. Pkm2+ mesenchymal stem cell-derived apoptotic vesicles decrease chronic periodontitis in mice.

    “Systemic administration of PKM2+ mesenchymal stem cell-derived apoVs (MSC-apoVs) effectively rescues apoptotic resistance, eliminates senescent cells, and mitigates CP phenotypes.”

    AnimalsCP mice

    PKM2⁺ apoptotic vesicle-mediated systemic senolytics ameliorate chronic periodontitis

    Bioactive materials4 Jul 2025

More on Chronic periodontitis

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