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Pharmacological enhancement of HSF1

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Animals1

Outcomes

3

Cognitive function

upin mice1

1 study

  1. Pharmacological enhancement of HSF1 improves cognitive function in mice.

    “pharmacologically enhancing HSF1 improved BAT senescence, metabolic decline, and cognitive dysfunction in aged mice.”

    Animals

    Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline

    eLife3 Oct 2025Preprint

Metabolic homeostasis

upin mice1

1 study

  1. Pharmacological enhancement of HSF1 improves metabolic homeostasis in mice.

    “pharmacologically enhancing HSF1 improved BAT senescence, metabolic decline, and cognitive dysfunction in aged mice.”

    Animals

    Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline

    eLife3 Oct 2025Preprint

brown adipose tissue senescence

downin mice1

1 study

  1. Pharmacological enhancement of HSF1 decreases brown adipose tissue senescence in mice.

    “pharmacologically enhancing HSF1 improved BAT senescence, metabolic decline, and cognitive dysfunction in aged mice.”

    Animalsbrown adipose tissue

    Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline

    eLife3 Oct 2025Preprint

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