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PF-04859989

Intervention

1 paper studies it1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Basic Public Welfare Research Program of Zhejiang Province and 1 more
  • Animals1

Outcomes

1

Cognitive function

upin mice1

1 study

  1. PF-04859989 improves cognitive function in mice.

    “KAT-II inhibitor (PF-04859989) reduced brain KYNA levels and restored the cognitive impairment.”

    Animalsin aged mice after exploratory laparotomy

    IDO-Kynurenine pathway mediates NLRP3 inflammasome activation-induced postoperative cognitive impairment in aged mice

    The International journal of neuroscienceSep 25, 2023

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