PF-04418948
- 2 independent labs in 1 country
- Funders: Colorado State University and 2 more
- 4 of 9 findings with company ties
- Animals2
Outcomes
6Cellular senescence
downin mice2
2 studies
Cellular senescence
downin mice2
PF-04418948 decreases cellular senescence in mice.
“decreasing both total macrophages (CD68+) and senescent macrophages (CD68+P21+)”
Animalsin DKO-Hom miceskeletal muscle2 weeks
CellsJan 14, 2025
PF-04418948 decreases cellular senescence in mice.
“decreasing both total macrophages (CD68+) and senescent macrophages (CD68+P21+)”
Animalsin DKO-Hom miceskeletal muscle2 weeks
Preprints.orgNov 4, 2024Preprint
Heterotopic ossification
downin mice2
2 studies
Heterotopic ossification
downin mice2
PF-04418948 decreases heterotopic ossification in mice.
“reduced HO and muscle pathology”
Animalsin DKO-Hom miceskeletal muscle2 weeks
CellsJan 14, 2025
PF-04418948 decreases heterotopic ossification in mice.
“Treatment of DKO-Hom mice with the EP2 antagonist PF04418948 for 2 weeks, increased body weight, reduced HO”
Animalsin DKO-Hom mice2 weeks
Preprints.orgNov 4, 2024Preprint
Body weight
upin mice2
2 studies
Body weight
upin mice2
PF-04418948 increases body weight in mice.
“Treatment of DKO-Hom mice with the EP2 antagonist PF04418948 for 2 weeks increased body weight”
Animalsin DKO-Hom mice2 weeks
CellsJan 14, 2025
PF-04418948 increases body weight in mice.
“Treatment of DKO-Hom mice with the EP2 antagonist PF04418948 for 2 weeks, increased body weight”
Animalsin DKO-Hom mice2 weeks
Preprints.orgNov 4, 2024Preprint
Bone volume fraction
upin mice1
1 study
Bone volume fraction
upin mice1
PF-04418948 increases bone volume fraction in mice.
“PF04418948 also increased bone volume/total volume (BV/TV), the trabecular thickness (Tb.Th) of the tibia trabecular bone, and the cortical bone thickness”
Animalsin DKO-Hom micebone2 weeks
CellsJan 14, 2025
Bone volume/total volume
upin mice1
1 study
Bone volume/total volume
upin mice1
PF-04418948 increases bone volume/total volume in mice.
“PF04418948 also increased bone volume/total volume (BV/TV), trabecular thickness (Tb.Th) of the tibia trabecular bone and the cortical bone thickness of both the femur and tibia”
Animalsin DKO-Hom micebone2 weeks
Preprints.orgNov 4, 2024Preprint
Muscle pathology
downin mice1
1 study
Muscle pathology
downin mice1
PF-04418948 decreases muscle pathology in mice.
“Treatment of DKO-Hom mice with the EP2 antagonist PF04418948 for 2 weeks, increased body weight, reduced HO and muscle pathology”
Animalsin DKO-Hom mice2 weeks
Preprints.orgNov 4, 2024Preprint