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Permethrin

Intervention

1 paper3 findings

PubChemChEBIMeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Ministero dell’Istruzione, dell’Università e della Ricerca
  • Animals1

Outcomes

3

Nurr1 promoter methylation

no changein rats1

1 study

  1. Permethrin has no effect on Nurr1 promoter methylation in rats.

    “No changes in Nurr1 promoter methylation in adolescent, adult and old rats were found.”

    Animalsstriatum15days

    In vivo and in silico studies to identify mechanisms associated with Nurr1 modulation following early life exposure to permethrin in rats

    Neuroscience5 Nov 2016

More on Nurr1 promoter methylation

α-synuclein aggregation

upin rats1

1 study

  1. Permethrin increases α-synuclein aggregation in rats.

    “Adult rats showed enhanced DNMT3b and α-synuclein aggregation compared to the control group”

    Animalsstriatum15days

    In vivo and in silico studies to identify mechanisms associated with Nurr1 modulation following early life exposure to permethrin in rats

    Neuroscience5 Nov 2016

Monomeric and aggregated α-synuclein

upin rats1

1 study

  1. Permethrin increases monomeric and aggregated α-synuclein in rats.

    “In striatum from adolescent rats we detected an increase in DNA methyltransferases (DNMTs) such as DNMT1, DNMT3a, Tyrosine hydroxylase, monomeric and aggregated α-synuclein protein levels.”

    Animalsstriatum15days

    In vivo and in silico studies to identify mechanisms associated with Nurr1 modulation following early life exposure to permethrin in rats

    Neuroscience5 Nov 2016

More on Monomeric and aggregated α-synuclein

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