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PEP2-8

Intervention

1 paper studies it2 findings

PubChem

Across all fields, 1 paper: none in people yet, 1 in animals

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Heart, Lung, and Blood Institute and 3 more
  • Animals1

Outcomes

2

Inflammation

downin mice1

1 study

  1. PEP2-8 inhibits inflammation in mice.

    “Pep2-8 administration significantly downregulates expression of NOX4, MAPK subunits, NF-κB, and secretion of pro-inflammatory cytokines”

    Animalsaged miceaortic archmales

    PCSK9 attenuates efferocytosis in endothelial cells and promotes vascular aging

    Theranostics

More on Inflammation

efferocytosis

upin mice1

1 study

  1. PEP2-8 improves efferocytosis in mice.

    “Pep2-8 treatment markedly restored efferocytosis in endothelium from the aged mice”

    Animalsaged miceaortic endotheliummales

    PCSK9 attenuates efferocytosis in endothelial cells and promotes vascular aging

    Theranostics

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