Pembrolizumab

Pembrolizumab has been studied in 5 papers since 2020: 3 observational studies in people, 2 reviews; 1 in the past year. It is an approved medicine. The newest paper, Jan 29, 2026: “Drug-induced hyponatremia associated with sodium-glucose cotransporter 2 inhibitors, immune checkpoint inhibitors, and targeted anticancer agents”.

InterventionApproved 2014

5 papers study itUpdated

MeSH

See all 5 papers on pembrolizumab

At a glance

2,190 trials, none about aging, 260 with no results posted.

Cells, worms or flies, mice and humans: nothing yet.
  • 2,190 trials, none about aging, 260 with no results posted
  • 968 of 2,190 trials sponsored by its developers
  • Humans3

Has pembrolizumab been tested in people?

0 of 2,190 about aging

Yes: 3 observational studies in people have been published, and 2,163 trials are registered.

Latest change Non-small cell lung cancer: Phase 3 → ApprovedNov 11, 2026

Approved

  • FDA Keytruda

    Sep 4, 2014Melanoma, Lung Cancer, Non-Small Cell, Unresectable or Metastatic Melanoma, nsclc, squamous nsclc, Classical Hodgkin Lymphoma, Head and Neck Squamous Cell Cancer, Malignant Pleural Mesothelioma, Primary Mediastinal Large B Cell Lymphoma, hnscc

  • EMA Keytruda

    Jul 17, 2015Melanoma, Hodgkin Disease, Carcinoma, Renal Cell, Carcinoma, Non-Small-Cell Lung, Carcinoma, Transitional Cell, Squamous Cell Carcinoma of Head and Neck, Urologic Neoplasms, Endometrial Neoplasms, Advanced Melanoma, Stage III Melanoma, non squamous non small cell lung carcinoma, Advanced Renal Cell Carcinoma, Biliary Cancer, Biliary Tract Carcinoma, Cervical Cancer, Classical Hodgkin Lymphoma, Colorectal Cancer, DMMR Colorectal Cancer, Endometrial Carcinoma, Head and Neck Squamous Cell Carcinoma, Locally Advanced Cervical Cancer, Locally Advanced Head and Neck Squamous Cell Carcinoma, Malignant Pleural Mesothelioma, Metastatic Colorectal Cancer, Metastatic Non-Small Cell Lung Carcinoma, Metastatic Non-Squamous Non-Small Cell Lung Carcinoma, Metastatic Squamous Non-Small Cell Lung Carcinoma, Metastatic Triple Negative Breast Cancer, Metastatic Urothelial Carcinoma, Mismatch Repair Deficient Colorectal Cancer, Oesophageal Carcinoma, Ovarian Cancer, Persistent, Recurrent, or Metastatic Cervical Cancer, Primary Peritoneal Carcinoma, Recurrent Endometrial Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma, Triple -Negative Breast Cancer, Urothelial Carcinoma, resectable muscle-invasive bladder cancer, locally advanced or metastatic urothelial carcinoma, recurrent or metastatic head and neck squamous cell carcinoma

Repurposing

40 of 191

In trials

  • Autosomal Dominant Lewy Body Parkinson Disease 4

    Phase 4Results posted162 trials

  • Ureteral Neoplasms

    Phase 4Recruiting11 trials

  • Triple negative breast neoplasm

    Phase 3Results posted135 trials

  • Prostatic neoplasm

    Phase 3Results posted39 trials

  • Fallopian tube neoplasm

    Phase 3Results posted30 trials

  • Adenocarcinoma Of Esophagus

    Phase 3Completed18 trials

40 of 142

Stopped

  • NCT03407170TerminatedAdvanced melanoma

    Lack of Accrual

  • NCT04738487TerminatedLung neoplasm

    Business Reasons

  • NCT03019588TerminatedStomach neoplasm

    Business Reasons

  • NCT05092360TerminatedOvarian neoplasm

    Study terminated due to business and strategic decision.

  • NCT04246177TerminatedHepatocellular carcinoma

    Business Reasons

  • NCT04777851TerminatedHepatocellular carcinoma

    The trial ended earlier than planned due to slow enrolment, which has made it unfeasible to achieve the target sample size within a reasonable timeframe. Consequently, a business decision has been made to discontinue funding for the trial.

40 of 68

Who is developing pembrolizumab?

3 companies: Merck Sharp & Dohme, NovoCure and Genmab.

Companies
  • Merck Sharp & DohmePhase 4neoplasm malignant, gastric neoplasms
  • NovoCurePhase 3glioblastoma
  • GenmabPhase 3PD-L1-positive, locally advanced (unresectable stage iiib/c) or metastatic NSCLC

Trial sponsors

Latest

Dec 2025: 0Jan 2026: 1Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 01 paper in 12 months