Pain

4 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funder: Department of Science and Technology of Sichuan Province

Humans4

Associations

Cognitive function

downin humans1

1 study

Pain is associated with cognitive function in humans.
“individuals with persistent moderate- and severe- levels of pain exhibited lower cognitive function compared to those with mild level of pain over time”
Humanspersistent moderate- and severe- levels of pain vs mild pain16 yearsn = 6,983
Longitudinal Associations Between Pain Trajectories and Cognitive Function: The Role of Neighborhood Context
GSA 2025 abstract31 Dec 2025

Liver disease

upin humans1HR 2.24

1 study

Pain raises the risk of liver disease in humans (HR 2.24, 95% CI: 1.56-3.22).
“those with "previously stronger pain" remained associated with 24%-124% elevated risks, especially for liver disease (HR 2.24, 95% CI: 1.56-3.22)”
Humanspreviously stronger pain
Pain as a precursor: elevated risk of chronic disease development in older adults-findings from dual aging prospective cohort studies and Mendelian randomization analysis
The journals of gerontology. Series A, Biological sciences and medical sciences5 Nov 2025