Ovarian transplantation

1. Ovarian transplantation has no effect on estradiol in mice (not increased compared with age-matched control mice).

   “Estradiol levels in transplant recipient mice were not increased compared with age-matched control mice.”

   Animalstransplant recipients vs age-matched controlsfemales

   Chronological and reproductive aging-associated changes in resistance to oxidative stress in post-reproductive female mice

   GeroScience·Jul 15, 2023

More on Estradiol

1. Ovarian transplantation decreases oxidative stress response proteins in mice (93% in follicle-containing young ovary recipients; 62% in follicle-depleted young ovary recipients).

   “In transplanted mice, far more proteins were decreased from 13 to 23 months (93% in follicle-containing young ovary recipients; 62% in follicle-depleted young ovary recipients).”

   Animalsin 23-month-old female mice transplanted at 13 monthsfollicle-containing or follicle-depleted young ovaryliverfemales

   Chronological and reproductive aging-associated changes in resistance to oxidative stress in post-reproductive female mice

   GeroScience·Jul 15, 2023

More on Oxidative stress response proteins

1. Ovarian transplantation improves burrowing behavior in mice.

   “We detected a significant age-related decrease in burrowing behavior at 16months of age. This age-related decrease in burrowing behavior was prevented by ovarian transplantation at 12months of age.”

   Animalsovary transplantation at 12 monthsfemales

   Cognitive behavior and sensory function were significantly influenced by restoration of active ovarian function in postreproductive mice

   Experimental gerontology·Mar 10, 2017

1. Ovarian transplantation decreases time spent on novel and familiar blocks in mice.

   “The olfactory discrimination block test revealed an age-associated increase in time spent on both the novel and familiar blocks. This trend was reversed in 16-month old new-ovary recipients.”

   Animalsovary transplantation at 12 monthsfemales

   Cognitive behavior and sensory function were significantly influenced by restoration of active ovarian function in postreproductive mice

   Experimental gerontology·Mar 10, 2017

1. Ovarian transplantation prevents olfactory identification decline in mice.

   “We found a significant age-related decline in olfactory identification in 16-month old mice. This decline was avoided by ovarian transplantation at 12months of age.”

   Animalsovary transplantation at 12 monthsfemales

   Cognitive behavior and sensory function were significantly influenced by restoration of active ovarian function in postreproductive mice

   Experimental gerontology·Mar 10, 2017

1. Ovarian transplantation decreases rate of weight loss to death in mice.

   “In addition, ovarian transplantation decreased the rate of weight loss to death.”

   Animalsfemales

   Ovarian status influenced the rate of body-weight change but not the total amount of body-weight gained or lost in female CBA/J mice

   Experimental gerontology·Mar 19, 2010

1. Ovarian transplantation extends lifespan in mice.

   “Life span was significantly increased in transplant recipients.”

   Animalsfemales

   Ovarian status influenced the rate of body-weight change but not the total amount of body-weight gained or lost in female CBA/J mice

   Experimental gerontology·Mar 19, 2010