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Organophosphorus pesticides

Organophosphorus pesticides has been studied in 3 papers since 2017: 3 observational studies in people. The newest paper, Jul 18, 2025: “Associations between organophosphorus pesticides exposure and age-related macular degeneration risk in U.S. adults: analysis from interpretable machine learning approaches”.

Exposure

3 papers study it3 findingsUpdated

See all 3

“Urinary DAP metabolites of OPPs exposure are associated with AMD risk”
Associations between organophosphorus pesticides exposure and age-related macular degeneration risk in U.S. adults: analysis from interpretable machine learning approachesInternational journal of ophthalmology2025doi:10.18240/ijo.2025.07.04

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: Burroughs Wellcome Fund and 7 more
  • Humans3

What did studies of Organophosphorus pesticides find?

1

Studies of Organophosphorus pesticides measured 1 outcome; the most studied are cognitive function (1 study).

Cognitive function

downin humans1

1 study

  1. Organophosphorus pesticides impair cognitive function in humans (β = 0.038, p = 0.02).

    “Participants with high OP exposure in the five years prior to baseline experienced faster cognitive decline (β = 0.038, p = 0.02)”

    Humansfive years prior to baselinen = 430

    Cognitive decline, mortality, and organophosphorus exposure in aging Mexican Americans

    Environmental research

What is Organophosphorus pesticides linked with?

2

Studies link Organophosphorus pesticides with 2 measures, most often age-related macular degeneration (1 study) and mortality (1).

Age-related macular degeneration

upin humans1

1 study

  1. Organophosphorus pesticides are associated with age-related macular degeneration in humans.

    “Urinary DAP metabolites of OPPs exposure are associated with AMD risk”

    HumansNHANES 2005-2008n = 1,845

    Associations between organophosphorus pesticides exposure and age-related macular degeneration risk in U.S. adults: analysis from interpretable machine learning approaches

    International journal of ophthalmology

More on Age-related macular degeneration

Mortality

upin humans1HR 1.91

1 study

  1. Organophosphorus pesticides raise the risk of mortality in humans (HR = 1.91, 95% CI = 1.12, 3.26).

    “higher mortality over follow-up (HR = 1.91, 95% CI = 1.12, 3.26)”

    Humansfive years prior to baselinen = 430

    Cognitive decline, mortality, and organophosphorus exposure in aging Mexican Americans

    Environmental research

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