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Oleracein e

Intervention

2 papers6 findings

PubChem

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 1 country
  • Funders: National Natural Science Foundation of China and 1 more
  • Animals2

Outcomes

6

mTOR signalling

downin mice1

1 study

  1. Oleracein e inhibits mTOR signalling in mice.

    “OE exerted its effects by inhibiting ERK1/2 phosphorylation and suppressing mTOR activation.”

    Animalsin hNSCs

    Oleracein E Rejuvenates Senescent Hippocampal NSCs by Inhibiting the ERK1/2-mTOR Axis to Improve Cognitive Dysfunction in Vascular Dementia

    The European journal of neuroscience1 May 2025

More on mTOR signalling

Cognitive function

upin mice1

1 study

  1. Oleracein e improves cognitive function in mice.

    “OE treatment significantly reduced hNSCs senescence, restored proliferation and neuronal differentiation capacities, and improved cognitive performance.”

    Animalsin a two-vessel occlusion mouse model of VD

    Oleracein E Rejuvenates Senescent Hippocampal NSCs by Inhibiting the ERK1/2-mTOR Axis to Improve Cognitive Dysfunction in Vascular Dementia

    The European journal of neuroscience1 May 2025

Cellular senescence

downin mice1

1 study

  1. Oleracein e decreases cellular senescence in mice.

    “OE treatment significantly reduced hNSCs senescence”

    Animalsin a two-vessel occlusion mouse model of VD

    Oleracein E Rejuvenates Senescent Hippocampal NSCs by Inhibiting the ERK1/2-mTOR Axis to Improve Cognitive Dysfunction in Vascular Dementia

    The European journal of neuroscience1 May 2025

More on Cellular senescence

Apoptosis

downin mice1

1 study

  1. Oleracein e inhibits apoptosis in mice.

    “inhibition of hippocampal neuronal apoptosis.”

    Animalsin D-galactose/NaNO2-induced senescent Kunming micehippocampus

    Racemic oleracein E increases the survival rate and attenuates memory impairment in D-galactose/NaNO₂-induced senescent mice

    Phytomedicine : international journal of phytotherapy and phytopharmacology3 Mar 2016

More on Apoptosis

Spatial memory

upin mice1

1 study

  1. Oleracein e improves spatial memory in mice.

    “Similar to PA, OE at 15 mg/kg/d improved memory capacity.”

    Animalsin D-galactose/NaNO2-induced senescent Kunming mice15 mg/kg/d8 weeks

    Racemic oleracein E increases the survival rate and attenuates memory impairment in D-galactose/NaNO₂-induced senescent mice

    Phytomedicine : international journal of phytotherapy and phytopharmacology3 Mar 2016

Lifespan

upin mice1

1 study

  1. Oleracein e extends lifespan in mice.

    “OE significantly prolonged lifespan and was more potent than PA.”

    Animalsin D-galactose/NaNO2-induced senescent Kunming mice8 weeks

    Racemic oleracein E increases the survival rate and attenuates memory impairment in D-galactose/NaNO₂-induced senescent mice

    Phytomedicine : international journal of phytotherapy and phytopharmacology3 Mar 2016

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