Old serum

Old serum impairs endothelial function in mice (mouse serum, P < 0.001; human serum, P = 0.006 vs. young serum control).

“impaired carotid artery endothelial function, assessed by endothelium-dependent dilation (EDD) (mouse serum, P < 0.001; human serum, P = 0.006 vs. young serum control).”

Animalsin young mouse carotid arteriescarotid artery

Role of the circulating milieu in age-related arterial dysfunction: a novel ex vivo approach

American journal of physiology. Heart and circulatory physiology·Mar 22, 2024

Old serum increases arterial stiffness in mice (P = 0.003 vs. young serum control).

“old mouse and ML/O adult human, but not young, serum stiffened young mouse aortic rings, assessed via elastic modulus (mouse and human serum, P = 0.003 vs. young serum control)”

Animalsin young mouse aortic ringsaorta

Role of the circulating milieu in age-related arterial dysfunction: a novel ex vivo approach

American journal of physiology. Heart and circulatory physiology·Mar 22, 2024