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NOTCH1-BLOCKING antibody

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: China Postdoctoral Science Foundation and 3 more
  • Animals1

Outcomes

1

Atheroprogression

downin mice1

1 study

  1. NOTCH1-BLOCKING antibody decreases atheroprogression in mice.

    “Notch1- or VCAM1-blocking antibodies and the genetic ablation of endothelial Notch1 reduced atheroprogression after stroke.”

    AnimalsAfter stroke

    Brain ischemia causes systemic Notch1 activity in endothelial cells to drive atherosclerosis

    Immunity29 Jul 2024

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