NON-CYP3A4-METABOLIZED statins

NON-CYP3A4-METABOLIZED statins are associated with major adverse cardiovascular events in humans (HR 0.87, 95% CI 0.78–0.96).

“The pooled comparison was concordant (HR, 0.87 [95% CI, 0.78-0.96]).”

HumansPatients with cancer receiving tyrosine kinase inhibitors; pooled comparison with atorvastatinDay 30 to up to 3 years

Association of Non-Cytochrome P450 3A4-Metabolized Statins Versus Atorvastatin With Major Adverse Cardiovascular Events in Patients With Cancer Receiving Tyrosine Kinase Inhibitors: A Propensity Score-Matched Target Trial Emulation

Journal of the American Heart Association·16 Oct 2026