Nkx2-5δhd
Intervention1 paper3 findings
- Animals1
Outcomes
3Frailty
downin mice1Very low certainty
1 study
Frailty
downin mice1Very low certainty
Nkx2-5δhd decreases frailty in mice.
Animalssystemic delivery
Engineered cardiac transcription factor restores vision and reduces frailty in aging mice · bioRxiv · 30 Sep 2026 · Preprint
Grip strength
upin mice1Very low certainty
1 study
Grip strength
upin mice1Very low certainty
Nkx2-5δhd improves grip strength in mice.
Animalssystemic delivery
Engineered cardiac transcription factor restores vision and reduces frailty in aging mice · bioRxiv · 30 Sep 2026 · Preprint
Visual function
upin mice1Very low certainty
1 study
Visual function
upin mice1Very low certainty
Nkx2-5δhd improves visual function in mice.
Animalssubretinal delivery
Engineered cardiac transcription factor restores vision and reduces frailty in aging mice · bioRxiv · 30 Sep 2026 · Preprint
Latest
1Engineered cardiac transcription factor restores vision and reduces frailty in aging mice
A genome-scale screen in retinal cells identified NKX2-5 variants that conferred oxidative resilience and improved physical function without…A genome-scale screen in retinal cells identified NKX2-5 variants that conferred oxidative resilience and improved physical function without detectable toxicity.