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Nitric oxide donors

Intervention

3 papers study it2 findings

Across all fields, 3 papers: none in people yet, 2 in animals, 1 review

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 2 independent labs in 2 countries
  • Funders: American Federation for Aging Research and others
  • 1 of 2 findings with company ties
  • Animals1
  • Model organisms1

Outcomes

2

Kidney function

upin mice1

1 study

  1. Nitric oxide donors improve kidney function in mice.

    “a nitric oxide donor normalized kidney function in adult hosts.”

    Animalsin adult Zfyve21 EC-/- micekidney

    ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging

    Kidney international

Long-term memory

upin G. bimaculatus1

1 study

  1. Nitric oxide donors improve long-term memory in G. bimaculatus (Restored to the level in 1-week-old crickets).

    “an NO donor and a cGMP analog were found to antagonize the age-related impairment of LTM formation”

    Model organismsinjected into the hemolymph before conditioningmales

    Activation of NO-cGMP Signaling Rescues Age-Related Memory Impairment in Crickets

    Frontiers in behavioral neuroscience

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